Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma
Houston Methodist · Baylor College of Medicine · +4 more institutions
Abstract
We generated MHC-independent chimeric antigen receptors (CARs) directed to the GD2 antigen expressed by neuroblastoma tumor cells and treated patients with this disease. Two distinguishable forms of this CAR were expressed in EBV-specific cytotoxic T lymphocytes (EBV-CTLs) and activated T cells (ATCs). We have previously shown that EBV-CTLs expressing GD2-CARs (CAR-CTLs) circulated at higher levels than GD2-CAR ATCs (CAR-ATCs) early after infusion, but by 6 weeks, both subsets became low or undetectable. We now report the long-term clinical and immunologic consequences of infusions in 19 patients with high-risk neuroblastoma: 8 in remission at infusion and 11 with active disease. Three of 11 patients with…
Citation impact
- FWCI
- 20.72
- Percentile
- 100%
- References
- 39
Authors
17- CUChrystal U. LouisCorresponding
Houston Methodist, Baylor College of Medicine, Methodist Hospital, Pediatrics and Genetics, Texas Children's Hospital, Children's Cancer Center
- BSBarbara Savoldo
Houston Methodist, Baylor College of Medicine, Methodist Hospital, Pediatrics and Genetics, Texas Children's Hospital
- GDGianpietro Dotti
Houston Methodist, Baylor College of Medicine, Methodist Hospital, Texas Children's Hospital
- MPMartin Pulé
Houston Methodist, Baylor College of Medicine, Methodist Hospital, Texas Children's Hospital
- EYEric Yvon
Houston Methodist, Baylor College of Medicine, Methodist Hospital, Texas Children's Hospital
Topics & keywords
- Chimeric antigen receptor
- Neuroblastoma
- Cytotoxic T cell
- Immunology
- Antigen
- Medicine
- Persistence (discontinuity)
- Immunotherapy
- Good health and well-being