Topologically associating domains are stable units of replication-timing regulation

A study of DNA replication timing in mouse and human cells reveals that replication domains (domains of the genome which replicate at the same time) share a correlation with topologically associating domains; these results reconcile cell-type-specific sub-nuclear compartmentalization with developmentally stable chromosome domains and offer a unified model for large scale chromosome structure and function. As part of the mouse ENCODE project, David Gilbert and colleagues study the relationship between replication timing and higher order chromatin domains in mouse and human. They find that boundaries of replication domains — domains within the genome which replicate at the same time — share a near one-to-one…

• NI
  National Institutes of Health

  Awards: GM083337, GM083337 and GM085354, GM085354
• NC
  National Cancer Institute

  Award: F31CA165863