The role of glutathione in cancer
City Of Hope National Medical Center · City of Hope · +1 more institution
Abstract
Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It instils several vital roles within a cell including antioxidation, maintenance of the redox state, modulation of the immune response and detoxification of xenobiotics. With respect to cancer, glutathione metabolism is able to play both protective and pathogenic roles. It is crucial in the removal and detoxification of carcinogens, and alterations in this pathway, can have a profound effect on cell survival. However, by conferring resistance to a number of chemotherapeutic drugs, elevated levels of glutathione in tumour cells…
Citation impact
- FWCI
- 3.62
- Percentile
- 100%
- References
- 101
Authors
3- GKGanesaratnam K. BalendiranCorresponding
City Of Hope National Medical Center, City of Hope, Beckman Research Institute
- RDRajesh Dabur
City Of Hope National Medical Center, City of Hope, Beckman Research Institute
- DADeborah A. Fraser
City Of Hope National Medical Center, City of Hope, Beckman Research Institute
Topics & keywords
- Glutathione
- Detoxification (alternative medicine)
- Cancer
- Cancer research
- Xenobiotic
- Cancer cell
- Immune system
- Carcinogen
- Good health and well-being