reviewNature reviews. NeuroscienceApr 2, 2009GOLD OA

The neuro-symphony of stress

MJMarian JoëlsTZTallie Z. Baram

University of Amsterdam · Amsterdam University of Applied Sciences · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Stress induces the release of many stress mediators in the brain. Joëls and Baram show that the spatial and temporal niches of action of these mediators overlap and discuss how different mediators interact to enable appropriate responses to diverse stressors. The impact of stress on brain function is increasingly recognized. Various substances are released in response to stress and can influence distinct neuronal circuits, but the functional advantages of having such a diversity of stress mediators remain unclear. Individual neurotransmitter, neuropeptide and steroid stress mediators have specific spatial and temporal niches, but these niches also overlap. In addition, the effects of individual mediators on…

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1,486
total citations
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18.00
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100%
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83
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Authors

2

Topics & keywords

Topics
Keywords
  • Neuroscience
  • Stressor
  • Crosstalk
  • Biology
  • Fight-or-flight response
  • Neuroplasticity
  • Stress (linguistics)
  • Psychology
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