Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Estrada, Karol; Styrkársdóttir, Unnur; Εvangelou, Εvangelos; Hsu, Yi‐Hsiang; Duncan, Emma L.; Ntzani, Evangelia; Oei, Ling; Albagha, Omar; Amin, Najaf; Kemp, John P.; Koller, Daniel L.; Guo, Li; Liu, Ching‐Ti; Minster, Ryan L.; Moayyeri, Alireza; Vandenput, Liesbeth; Willner, Dana; Xiao, Su‐Mei; Yerges-Armstrong, Laura M.; Zheng, Hou‐Feng; Alonso, Nerea; Eriksson, Joel; Kammerer, Candace M.; Kaptoge, Stephen K.; Leo, Paul; Þorleifsson, Guðmar; Wilson, Scott G.; Wilson, James F.; Aalto, Ville; Alén, Markku; Aragaki, Aaron K.; Aspelund, Thor; Dailiana, Zoe; Duggan, David; García, Melissa; García‐Giralt, Natalia; Giroux, Sylvie; Hallmans, Göran; Hocking, Lynne J.; Husted, Lise B.; James, Anthony; Хусаинова, Р. И.; Kim, Ghi Su; Kooperberg, Charles; Koromila, Theodora; Kruk, Marcin; Laaksonen, Marika; LaCroix, Andrea Z.; Lee, Seung Hun; Leung, Ping‐Chung; Lewis, Joshua R.; Masi, Laura; Mencej-Bedrač, Simona; Nguyen, Tuan V.; Nogués, Xavier; Patel, Millan S.; Preželj, Janez; Rose, Lynda M.; Scollen, Serena; Siggeirsdóttir, Kristín; Smith, Albert V.; Svensson, Olle; Trompet, Stella; Trummer, Olivia; Schoor, Natasja M. van; Woo, Jean; Zhu, Kun; Balcells, Susana; Brandi, Maria Luisa; Buckley, Brendan M.; Cheng, Sulin; Christiansen, Claus; Cooper, Cyrus; Dedoussis, George; Ford, Ian; Frost, Morten; Goltzman, David; González-Macı́as, Jesús; Kähönen, Mika; Karlsson, Magnus K.; Хуснутдинова, Э. К.; Koh, Jung‐Min; Κollia, Panagoula; Langdahl, Bente; Leslie, William D.; Lips, Paul; Ljunggren, Östen; Lorenc, R; Marc, Janja; Mellström, Dan; Obermayer‐Pietsch, Barbara; Olmos, José M.; Pettersson, U.; Reid, David M.; Riancho, José A.; Ridker, Paul M.; Rousseau, François; Slagboom, P. Eline; Tang, Nelson L.S.; Urreizti, Roser; Hul, Wim Van; Viikari, Jorma; Zarrabeitia, Marı́a T.; Aulchenko, Yurii S.; Castaño‐Betancourt, Martha C.; Grundberg, Elin; Herrera, Lizbeth; Ingvarsson, Þorvaldur; Johannsdottir, Hrefna; Kwan, Tony; Li, Rui; Luben, Robert; Medina‐Gómez, Carolina; Palsson, Stefan; Reppe, Sjur; Rotter, Jerome I.; Sigurðsson, Gunnar; Meurs, Joyce B. J. van; Verlaan, Dominique J.; Williams, Frances M. K.; Wood, Andrew R.; Zhou, Yanhua; Gautvik, Kaare M.; Pastinen, Tomi; Raychaudhuri, Soumya; Cauley, Jane A.; Chasman, Daniel I.; Clark, Graeme R.; Cummings, Steven R.; Danoy, Patrick; Dennison, Elaine; Eastell, Richard; Eisman, John A.; Guðnason, Vilmundur; Hofman, Albert; Jackson, Rebecca D.; Jones, Graeme; Jukema, J. Wouter; Khaw, Kay‐Tee; Lehtimäki, Terho; Liu, Ching‐Ti; Lorentzon, Mattias; McCloskey, Eugène; Mitchell, Braxton D.; Nandakumar, Kannabiran; Nicholson, Geoffrey C.; Oostra, Ben A.; Peacock, Munro; Pols, Huibert A. P.; Prince, Richard L.; Raitakari, Olli; Reid, Ian R.; Robbins, John A.; Sambrook, Philip N.; Sham, Pak C.; Shuldiner, Alan R.; Tylavsky, Frances A.; Duijn, Cornelia M. van; Wareham, Nick J; Cupples, L. Adrienne; Econs, Michael J.; Evans, David M.; Harris, Tamara B.; Kung, A W; Psaty, Bruce M.; Reeve, J.; Spector, Timothy D.; Streeten, Elizabeth A.; Zillikens, M. Carola; Þorsteinsdóttir, Unnur; Ohlsson, Claes; Karasik, David; Richards, J. Brent; Brown, Matthew A.; Stefánsson, Kāri; Uitterlinden, André G.; Ralston, Stuart H.; Ioannidis, John P. A.; Kiel, Douglas P.; Rivadeneira, Fernando

doi:10.1038/ng.2249

reviewNature GeneticsApr 15, 2012GREEN OA

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

KEKarol Estrada USUnnur Styrkársdóttir ΕΕΕvangelos Εvangelou YHYi‐Hsiang Hsu ELEmma L. Duncan

Erasmus MC · deCODE Genetics (Iceland) · +94 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

1,214

total citations

FWCI: 83.49
Percentile: 100%
References: 56

Citations per year

Authors

180

KE
Karol EstradaCorresponding
Erasmus MC
US
Unnur Styrkársdóttir
deCODE Genetics (Iceland)
ΕΕ
Εvangelos Εvangelou
University of Ioannina
YH
Yi‐Hsiang Hsu
Hebrew SeniorLife
EL
Emma L. Duncan
The University of Queensland

Topics & keywords

Topics

Bone health and osteoporosis research100%
Bone Metabolism and Diseases100%
Genetic Associations and Epidemiology99%

Keywords

Genome-wide association study
Bone mineral
Biology
Osteoporosis
Bone density
Genetic association
Genetics
Internal medicine

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

DW
Donald W. Reynolds Foundation
A
Amgen
EL
Eli Lilly and Company
P
Pfizer
S
Sanofi
PA
Procter and Gamble
UO
University of Michigan
GR
Geelong Region Medical Research Foundation
WT
Wellcome Trust
Awards: 223004, FP7/2007-2013
DF
Dairy Farmers of Canada
CD
Chronic Disease Research Foundation
SG
Scottish Government
CM
Cedars-Sinai Medical Center
AF
Austrian Federal Ministry of Economy, Family and Youth
KF
Kempe Foundation
Award: JCK-1021
AS
Arthritis Society
NI
National Institute for Health and Care Research
Awards: 96,97, FP7/2007-2013
BH
British Heart Foundation
KC
King's College London
EC
European Commission
Awards: 018947, FP7/2007-2013, 89,90, 201865, 2007-2013, FP7/2007, 34,35, HEALTH-F2-2008-201865-GEFOS, 28,29, 24,25, 223004, HEALTH-F2-2008-201865, LSHG-CT-2006-018947
AC
Australian Cancer Research Foundation
H
Healthway
Awards: 572604, 254627, 303169
FL
Fondation Leducq
SF
Stiftelsen för Strategisk Forskning
WA
World Anti-Doping Agency
K
Kela
SK
Suomen Kulttuurirahasto
NO
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Awards: 911-03-012, 050-060-810, 175.010.2005.011, 15707, FP7/2007-2013
UO
University of Hong Kong
MO
Ministry of Agriculture, Forestry and Fisheries
JV
Juho Vainion Säätiö
NN
Novo Nordisk
V
Vetenskapsrådet
Awards: FP7/2007-2013, 2006-3832
JG
Jewish General Hospital
EA
Emil Aaltosen Säätiö
BF
Bundesministerium für Verkehr, Innovation und Technologie
NA
National and Kapodistrian University of Athens
GL
Göteborgs Läkaresällskap
SU
Syddansk Universitet
TT
Tampereen Tuberkuloosisäätiö
SL
Svenska Läkaresällskapet
SW
Steirische Wirtschaftsförderungsgesellschaft
PN
Paavo Nurmen Säätiö
S
Servier
TY
Turun Yliopistollinen Keskussairaala
Award: 9M048
K
Kulturministeriet
H
Hjartavernd
Award: N01-AG-12100
CF
Centre for Medical Systems Biology
NI
National Institutes of Health
Awards: N01AG62106, R01 AR/AG 41398, T32AG000262, HL105756, FP7/2007-2013, N01-HC-85079, N01-HC-75150, HL080295, AG-15928, R01 AG18728, N01 HC-55222, AG-023629, DK063491, N01-HC-85239, N01-AG-12100, HL69757, P30DK072488, N01-HC-25195, N01 HC-15103, HHSN268200782096C, N01-HC-35129, RR00425, N01-HC-85086, AG-20098, AG-027058, N01-HC-45133, U01 HL084756, N01AG62101, N01AG62103, M01-RR00425
CO
College of Pharmacy, University of Michigan
AC
Amgen Canada
EL
Eli Lilly Canada
CI
Canadian Institutes of Health Research
Awards: 15389, N01-HC-25195
MR
Medical Research Council
Awards: G0800582, LSHG-CT-2006-018947, HHSN268200782096C
NH
National Health and Medical Research Council
Awards: 511132, 572604, 254627, 303169 and 572604, 303169, 628582, 254627
HR
Health Research Council of New Zealand
Award: 2007-2013
ID
Instituto de Salud Carlos III
Award: PI 06/0034
EU
Erasmus Universitair Medisch Centrum Rotterdam
NI
National Institute on Aging
Awards: AG-023629, N01-HC-85086, AG-15928, N02-HL-6-4278, N01 HC-15103, N01-HC-25195, N01-HC-75150, N01-HC-45133, N01-AG-12100, N01-HC-35129, N01-HC-85079, AG-027058, N01 HC-55222, N01-HC-85239, N01AG62103, N01AG62106, HL080295, N01AG62101, AG-20098, T32AG000262
NH
National Heart, Lung, and Blood Institute
Awards: AG-023629, AG-027058, N02-HL-6-4278, HL105756, AG-20098, N01-HC-85239, N01-HC-75150, N01-HC-35129, U01 HL084756, N01AG62101, HL087652, N01-HC-85079, N01-HC-45133, N01AG62106, N01-HC-85086, N01-HC-25195, N01 HC-15103, N01AG62103, N01 HC-55222, AG-15928, DK063491, HL080295
NC
National Cancer Institute
NI
National Institute of Diabetes and Digestive and Kidney Diseases
Awards: DK063491, N01-HC-25195, P30DK072488, 126925, M01-RR00425
NI
National Institute of Neurological Disorders and Stroke
Awards: AG-15928, N01-HC-85239, N01-HC-75150, HL080295, AG-20098, N01-HC-35129, AG-027058, N01-HC-25195, AG-023629, N01-HC-45133, DK063491, N01 HC-15103, N01-HC-85079, N02-HL-6-4278, N01-HC-85086, N01 HC-55222, R01 AR/AG 41398
NC
National Center for Research Resources
Awards: HL105756, M01-RR00425