reviewEuropean Heart JournalApr 17, 2015BRONZE OA

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

PSPetar SeferovićWJWalter J. Paulus

Amsterdam UMC Location VUmc

PubMed
Indexed incrossrefpubmed

Abstract

Diabetes mellitus-related cardiomyopathy (DMCMP) was originally described as a dilated phenotype with eccentric left ventricular (LV) remodelling and systolic LV dysfunction. Recently however, clinical studies on DMCMP mainly describe a restrictive phenotype with concentric LV remodelling and diastolic LV dysfunction. Both phenotypes are not successive stages of DMCMP but evolve independently to respectively heart failure with preserved left ventricular ejection fraction (HFPEF) or reduced left ventricular ejection fraction (HFREF). Phenotype-specific pathophysiological mechanisms were recently proposed for LV remodelling and dysfunction in HFPEF and HFREF consisting of coronary microvascular endothelial…

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544
total citations
FWCI
28.52
Percentile
100%
References
126
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Medicine
  • Cardiology
  • Internal medicine
  • Dilated cardiomyopathy
  • Heart failure
  • Heart failure with preserved ejection fraction
  • Diabetic cardiomyopathy
  • Ejection fraction
UN Sustainable Development Goals
  • Good health and well-being
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