Brain Systems Mediating Cognitive Interference by Emotional Distraction

Flexible behavior depends on our ability to cope with distracting stimuli that can interfere with the attainment of goals. Emotional distracters can be particularly disruptive to goal-oriented behavior, but the neural systems through which these detrimental effects are mediated are not known. We used event-related functional magnetic resonance imaging to investigate the effect of emotional and nonemotional distracters on a delayed-response working memory (WM) task. As expected, this task evoked robust activity during the delay period in typical WM regions (dorsolateral prefrontal cortex and lateral parietal cortex). Presentation of emotional distracters during the delay interval evoked strong activity in…

• UD
  U.S. Department of Veterans Affairs
• NI
  National Institutes of Health

  Awards: MH60451, NS41328
• NC
  NIH Clinical Center