reviewImmunological ReviewsDec 19, 2008GREEN OA

Innate immunity to virus infection

OTOsamu TakeuchiSAShizuo Akira

The University of Osaka

PubMed
Indexed incrossrefpubmed

Abstract

The innate immune system is essential for the initial detection of invading viruses and subsequent activation of adaptive immunity. Three classes of receptors, designated retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), Toll-like receptors (TLRs), and nucleotide oligomerization domain (NOD)-like receptors (NLRs), sense viral components, such as double-stranded RNA (dsRNA), single-stranded RNA, and DNA. RLRs and TLRs play essential roles in the production of type I interferons (IFNs) and proinflammatory cytokines in cell type-specific manners. While the RLRs play essential roles in the recognition of RNA viruses in various cells, plasmacytoid dendritic cells utilize TLRs for detecting virus…

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1,219
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23.55
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100%
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111
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Authors

2

Topics & keywords

Topics
Keywords
  • Biology
  • Innate immune system
  • Pattern recognition receptor
  • Acquired immune system
  • Intrinsic immunity
  • Immune system
  • Virology
  • Proinflammatory cytokine
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