DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
University of California, Los Angeles · UCLA Health · +2 more institutions
Abstract
In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG-binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the Bdnf gene. Moreover, increased Bdnf transcription involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter. Our findings suggest that DNA methylation-related chromatin remodeling is important for…
Citation impact
- FWCI
- 27.27
- Percentile
- 100%
- References
- 28
Authors
8- KMKeri Martinowich
University of California, Los Angeles, UCLA Health, UCLA Medical Center, Institute of Human Genetics
- DHDaisuke HattoriCorresponding
University of California, Los Angeles, UCLA Health, UCLA Medical Center, Institute of Human Genetics
- HWHao WuCorresponding
University of California, Los Angeles, UCLA Health, UCLA Medical Center, Institute of Human Genetics
- SDShaun D. FouseCorresponding
University of California, Los Angeles, UCLA Health, UCLA Medical Center, Institute of Human Genetics
- FHFei He
University of California, Los Angeles, UCLA Health, UCLA Medical Center, Institute of Human Genetics
Topics & keywords
- Chromatin remodeling
- DNA methylation
- Biology
- Epigenetics of physical exercise
- MECP2
- Histone
- Chromatin
- Histone methylation