Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Harvard University · Harvard Stem Cell Institute · +4 more institutions
Abstract
In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells. Therefore, restoring the functionality of the niche should counteract some of the negative effects of aging. We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice. Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis. The identification of factors that slow the…
Citation impact
- FWCI
- 45.91
- Percentile
- 100%
- References
- 38
Authors
10- LKLida KatsimpardiCorresponding
Harvard University, Harvard Stem Cell Institute
- NKNadia K. Litterman
Harvard University, Harvard Stem Cell Institute
- PAPamela A. Schein
Harvard University, Harvard Stem Cell Institute
- CMChristine Miller
Joslin Diabetes Center, Howard Hughes Medical Institute, Harvard University, Harvard Stem Cell Institute
- FSFrancesco S. Loffredo
Brigham and Women's Hospital, Harvard University, Harvard Stem Cell Institute
Topics & keywords
- Neurogenesis
- Neuroscience
- Neural stem cell
- Biology
- Neurovascular bundle
- Central nervous system
- Cognitive decline
- Stem cell