Physiology of Microglia
Kyushu University · Max Delbrück Center · +2 more institutions
Abstract
Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specific ramified morphological phenotype termed "resting microglia." Recent studies indicate that even in the normal brain, microglia have highly motile processes by which they scan their territorial domains. By a large number of signaling pathways they can communicate with macroglial cells and neurons and with cells of the immune system. Likewise, microglial cells express receptors classically described for brain-specific communication such as neurotransmitter receptors and…
Citation impact
- FWCI
- 135.49
- Percentile
- 100%
- References
- 1,055
Authors
4- HKHelmut KettenmannCorresponding
Kyushu University, Max Delbrück Center, University of Manchester, University of Göttingen
- UHUwe‐Karsten Hanisch
Kyushu University, Max Delbrück Center, University of Manchester, University of Göttingen
- MNMami Noda
Kyushu University, Max Delbrück Center, University of Manchester, University of Göttingen
- AVAlexei VerkhratskyCorresponding
Kyushu University, Max Delbrück Center, University of Manchester, University of Göttingen
Topics & keywords
- Microglia
- Biology
- Central nervous system
- Neuroscience
- Immune system
- Cell type
- Neuroinflammation
- Cell biology