articleCirculationDec 22, 2009BRONZE OA

Brain Volume and Metabolism in Fetuses With Congenital Heart Disease

CLCatherine LimperopoulosWTWayne TworetzkyDBDoff B. McElhinneyJWJane W. NewburgerDWDavid W. Brown

Neurology, Inc · McGill University

PubMed
Indexed incrossrefpubmed

Abstract

BACKGROUND: Adverse neurodevelopmental outcome is an important source of morbidity in children with congenital heart disease (CHD). A significant proportion of newborns with complex CHD have abnormalities of brain size, structure, or function, which suggests that antenatal factors may contribute to childhood neurodevelopmental morbidity. METHODS AND RESULTS: Brain volume and metabolism were compared prospectively between 55 fetuses with CHD and 50 normal fetuses with the use of 3-dimensinal volumetric magnetic resonance imaging and proton magnetic resonance spectroscopy. Fetal intracranial cavity volume, cerebrospinal fluid volume, and total brain volume were measured by manual segmentation. Proton magnetic…

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656
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Authors

14

Topics & keywords

Topics
Keywords
  • Medicine
  • Gestational age
  • Fetus
  • Choline
  • Magnetic resonance imaging
  • Cardiology
  • Fetal echocardiography
  • Brain size
UN Sustainable Development Goals
  • Good health and well-being
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