Comprehensive molecular characterization of urothelial bladder carcinoma

Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. So far, no molecularly targeted agents have been approved for treatment of the disease. As part of The Cancer Genome Atlas project, we report here an integrated analysis of 131 urothelial carcinomas to provide a comprehensive landscape of molecular alterations. There were statistically significant recurrent mutations in 32 genes, including multiple genes involved in cell-cycle regulation, chromatin regulation, and kinase signalling pathways, as well as 9 genes not previously reported as significantly mutated in any cancer. RNA sequencing revealed four expression subtypes, two of which…

• SI
  SRA International
• BA
  Brigham and Women's Hospital
• UO
  University of Miami
• MI
  Massachusetts Institute of Technology
• MS
  Memorial Sloan-Kettering Cancer Center
• HU
  Harvard University
• UO
  University of Chicago
• CC
  Cleveland Clinic
• CC
  Cleveland Clinic Foundation
• NC
  Nationwide Children's Hospital
• UO
  University of Texas Southwestern Medical Center
• UO
  University of Pittsburgh
• DL
  Dan L. Duncan Cancer Center, Baylor College of Medicine
• BI
  Broad Institute
• SC
  Sylvester Comprehensive Cancer Center, University of Miami Health Systems
• NI
  National Institutes of Health

  Awards: U24 CA143882, U54 HG003079, U24 CA143866, U54 HG003067, U24 CA143799, CA143835, U24 CA143835, CA120964, U24 CA143843, U24 CA144025, HG003079, U54 HG003273, CA143883, U24 CA143845, U24 CA143848, U24 CA143858, HG003067, U24 CA143883, U24 CA143840, P01 CA120964, U24 CA143867
• UO
  University of Texas MD Anderson Cancer Center
• UO
  University of North Carolina at Chapel Hill
• UO
  University of California, San Diego
• SO
  School of Medicine, Indiana University
• RI
  Research Institute, Nationwide Children's Hospital
• NC
  National Cancer Institute

  Awards: U24 CA143799, CA120964, P01 CA120964, U24 CA143835, U24 CA143867, U54 HG003273, U54 HG003067, U24 CA143866, U24 CA143845, CA143883, U24 CA143883, U24 CA143848, U24 CA143858, U24 CA144025, U24 CA143843, U24 CA143840, CA143840, U24 CA143882, U54 HG003079
• LC
  Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill