The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
Université Toulouse III - Paul Sabatier · Université Fédérale de Toulouse Midi-Pyrénées · +1 more institution
Abstract
IL-33 is a chromatin-associated cytokine of the IL-1 family that has recently been linked to many diseases, including asthma, rheumatoid arthritis, atherosclerosis, and cardiovascular diseases. IL-33 signals through the IL-1 receptor-related protein ST2 and drives production of pro-inflammatory and T helper type 2-associated cytokines in mast cells, T helper type 2 lymphocytes, basophils, eosinophils, invariant natural killer T cells, and natural killer cells. It is currently believed that IL-33, like IL-1beta and IL-18, requires processing by caspase-1 to a mature form (IL-33(112-270)) for biological activity. Contrary to the current belief, we report here that full-length IL-33(1-270) is active and that…
Citation impact
- FWCI
- 19.67
- Percentile
- 100%
- References
- 37
Authors
2- CCCorinne Cayrol
Université Toulouse III - Paul Sabatier, Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale
- JGJean‐Philippe GirardCorresponding
Université Toulouse III - Paul Sabatier, Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale
Topics & keywords
- Cytokine
- Interleukin 33
- Caspase 1
- Cell biology
- Biology
- Caspase
- Immunology
- Interleukin 12
- Good health and well-being