Precision High-Throughput Proton NMR Spectroscopy of Human Urine, Serum, and Plasma for Large-Scale Metabolic Phenotyping
Hammersmith Hospital · Imperial College London · +2 more institutions
Abstract
Proton nuclear magnetic resonance (NMR)-based metabolic phenotyping of urine and blood plasma/serum samples provides important prognostic and diagnostic information and permits monitoring of disease progression in an objective manner. Much effort has been made in recent years to develop NMR instrumentation and technology to allow the acquisition of data in an effective, reproducible, and high-throughput approach that allows the study of general population samples from epidemiological collections for biomarkers of disease risk. The challenge remains to develop highly reproducible methods and standardized protocols that minimize technical or experimental bias, allowing realistic interlaboratory comparisons of…
Citation impact
- FWCI
- 14.80
- Percentile
- 100%
- References
- 47
Authors
10Topics & keywords
- Metabolomics
- Chemistry
- Reproducibility
- Population
- Throughput
- Nuclear magnetic resonance spectroscopy
- Biomarker
- Instrumentation (computer programming)
- Good health and well-being