Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity
West Virginia University · National Institute for Occupational Safety and Health
Abstract
The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. The unique physicochemical and electrical properties of engineered nanoparticles (NP) make them highly desirable in a variety of applications. However, these novel properties of NP are fraught with concerns for environmental and occupational exposure. Changes in structural and physicochemical properties of NP can lead to changes in biological activities including ROS generation, one of the most frequently reported NP-associated toxicities. Oxidative stress induced by engineered NP is due to acellular factors such as particle surface, size, composition, and presence of metals, while…
Citation impact
- FWCI
- 37.75
- Percentile
- 100%
- References
- 177
Authors
3Topics & keywords
- Oxidative stress
- Reactive oxygen species
- Cell biology
- Toxicity
- Chemistry
- Oxidative phosphorylation
- Inflammation
- Fibrosis
- Industry, innovation and infrastructure