Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells
UCLA Medical Center · The Lundquist Institute · +4 more institutions
Abstract
Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal candidiasis. Both of these diseases are characterized by fungal invasion of host cells. Previously, we have found that C. albicans hyphae invade endothelial cells and oral epithelial cells in vitro by inducing their own endocytosis. Therefore, we set out to identify the fungal surface protein and host cell receptors that mediate this process. We found that the C. albicans Als3 is required for the organism to be endocytosed by human umbilical vein endothelial cells and two different human oral epithelial lines. Affinity purification experiments with wild-type and an als3delta/als3delta mutant strain of C. albicans…
Citation impact
- FWCI
- 15.28
- Percentile
- 100%
- References
- 67
Authors
9- QTQuynh T. Phan
UCLA Medical Center, The Lundquist Institute, Harbor–UCLA Medical Center
- CLCarter L. Myers
Harbor–UCLA Medical Center, UCLA Medical Center, The Lundquist Institute
- YFYue Fu
UCLA Medical Center, Harbor–UCLA Medical Center, University of California, Los Angeles, The Lundquist Institute
- DCDonald C. Sheppard
McGill University
- MRMichael R. Yeaman
UCLA Medical Center, Harbor–UCLA Medical Center, The Lundquist Institute, University of California, Los Angeles
Topics & keywords
- Endocytosis
- Candida albicans
- Cadherin
- Biology
- Corpus albicans
- Microbiology
- Cell biology
- Umbilical vein