Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis

Eknoyan, Garabed; Beck, Gerald J.; Cheung, Alfred K.; Daugirdas, John T.; Greene, Tom; Kusek, John W.; Allon, Michael; Bailey, James L.; Delmez, James A.; Depner, Thomas A.; Dwyer, Johanna; Levey, Andrew S.; Levin, Nathan W.; Milford, Edgar L.; Ornt, Daniel B.; Rocco, Michael V.; Schulman, Gerald; Schwab, Steve J.; Teehan, Brendan P.; Toto, Robert D.

doi:10.1056/nejmoa021583

articleNew England Journal of MedicineDec 18, 2002BRONZE OA

Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis

GEGarabed Eknoyan GJGerald J. Beck AKAlfred K. Cheung JTJohn T. Daugirdas TGTom Greene

Baylor College of Medicine · Cleveland Clinic · +17 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Background

The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain.

Methods

We undertook a randomized clinical trial in 1846 patients undergoing thrice-weekly dialysis, using a two-by-two factorial design to assign patients randomly to a standard or high dose of dialysis and to a low-flux or high-flux dialyzer.

Citation impact

1,872

total citations

FWCI: 39.31
Percentile: 100%
References: 38

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Authors

20

Topics & keywords

Topics

Keywords

Medicine
Confidence interval
Dialysis
Hemodialysis
Kt/V
Randomized controlled trial
Flux (metallurgy)
Relative risk

UN Sustainable Development Goals

Good health and well-being

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