Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives
Chinese University of Hong Kong · University of Hong Kong · +1 more institution
Abstract
Mesenchymal stem cells (MSCs) are one of a few stem cell types to be applied in clinical practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition to their multipotent differentiation potential, a strong paracrine capacity has been proposed as the principal mechanism that contributes to tissue repair. Apart from cytokine/chemokine secretion, MSCs also display a strong capacity for mitochondrial transfer and microvesicle (exosomes) secretion in response to injury with subsequent promotion of tissue regeneration. These unique properties of MSCs make them an invaluable cell type to repair damaged tissues/organs. Although MSCs offer great promise in the treatment of degenerative…
Citation impact
- FWCI
- 14.84
- Percentile
- 100%
- References
- 138
Authors
5- XLXiaoting Liang
Chinese University of Hong Kong, University of Hong Kong
- YDYue Ding
Chinese University of Hong Kong, Xiamen University, University of Hong Kong
- YZYuelin Zhang
Chinese University of Hong Kong, University of Hong Kong
- HTHung‐Fat Tse
Chinese University of Hong Kong, University of Hong Kong
- QLQizhou LianCorresponding
Chinese University of Hong Kong, University of Hong Kong
Topics & keywords
- Paracrine signalling
- Mesenchymal stem cell
- Microvesicles
- Exosome
- Microvesicle
- Regeneration (biology)
- Stem cell
- Cell biology
- Good health and well-being