Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs
University of California, Los Angeles · California NanoSystems Institute
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Abstract
Special delivery: The hydrophobic anticancer drug camptothecin was incorporated into fluorescent mesoporous silica nanoparticles (see image) and delivered to various cancer cells to induce cell death. These results suggest a method to overcome the insolubility problem of many anticancer drugs, which is considered to be one of the major challenges in cancer therapy.
Citation impact
1,004
total citations
- FWCI
- 33.73
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- 100%
- References
- 29
Citations per year
Authors
4- JLJie LüCorresponding
University of California, Los Angeles, California NanoSystems Institute
- MLMonty Liong
California NanoSystems Institute, University of California, Los Angeles
- JIJeffrey I. Zink
University of California, Los Angeles
- FTFuyuhiko Tamanoi
California NanoSystems Institute, University of California, Los Angeles
Topics & keywords
Topics
Keywords
- Mesoporous silica
- Camptothecin
- Drug delivery
- Nanoparticle
- Nanotechnology
- Anticancer drug
- Cancer therapy
- Cancer cell
UN Sustainable Development Goals
- Good health and well-being
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