The Human Serum Metabolome

Psychogios, Nikolaos; Hau, David; Peng, Jun; Guo, An Chi; Mandal, Rupasri; Bouatra, Souhaila; Sinelnikov, Igor; Krishnamurthy, Ramanarayan; Eisner, Roman; Gautam, Bijaya; Young, Nelson D.; Xia, Jianguo; Knox, Craig; Dong, Edison; Huang, Paul H.; Hollander, Zsuzsanna; Pedersen, Theresa L.; Smith, Steven R.; Bamforth, Fiona; Greiner, Russell; McManus, Bruce M.; Newman, John W.; Goodfriend, Theodore L.; Wishart, David S.

doi:10.1371/journal.pone.0016957

articlePLoS ONEFeb 16, 2011GOLD OA

The Human Serum Metabolome

NPNikolaos Psychogios DHDavid Hau JPJun Peng ACAn Chi Guo RMRupasri Mandal

University of Alberta · Prevention of Organ Failure · +5 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a…

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Topics

Keywords

Metabolome
Metabolomics
Metabolite
Human disease
Human physiology
Computational biology
Biology
Bioinformatics

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