PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer
Centre National de la Recherche Scientifique · Inserm · +7 more institutions
Abstract
Head and neck cancers positive for human papillomavirus (HPV) have a more favorable clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We hypothesized that prognosis was affected by intrinsic features of HPV-infected tumor cells or differences in host immune response. In this study, we focused on a comparison of regulatory Foxp3(+) T cells and programmed death-1 (PD-1)(+) T cells in the microenvironment of tumors that were positive or negative for HPV, in two groups that were matched for various clinical and biologic parameters. HPV-positive head and neck cancers were more heavily infiltrated by regulatory T cells and PD-1(+) T cells and the levels of PD-1(+) cells were…
Citation impact
- FWCI
- 16.11
- Percentile
- 100%
- References
- 61
Authors
30- CBCécile BadoualCorresponding
Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Paris Cardiovascular Research Center, Hôpital Bichat-Claude-Bernard, Biologie cellulaire et Cancer
- SHStéphane Hans
Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Paris Cardiovascular Research Center, Hôpital Bichat-Claude-Bernard, Biologie cellulaire et Cancer
- NMNathalie Merillon
Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Paris Cardiovascular Research Center, Hôpital Bichat-Claude-Bernard, Biologie cellulaire et Cancer
- CVCordélia Van Ryswick
Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Paris Cardiovascular Research Center, Hôpital Bichat-Claude-Bernard, Biologie cellulaire et Cancer
- PRPatrice Ravel
Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Paris Cardiovascular Research Center, Hôpital Bichat-Claude-Bernard, Biologie cellulaire et Cancer
Topics & keywords
- Medicine
- Immune system
- Cancer
- Blockade
- FOXP3
- Tumor microenvironment
- Head and neck cancer
- Cancer cell
- Good health and well-being