In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter cotranslationally in the ER lumen, which contains resident molecular chaperones and folding factors that assist their maturation. Native proteins are released from the ER lumen and are transported through the secretory pathway to their final intra- or extracellular destination. Folding-defective polypeptides are exported across the ER membrane into the cytosol and destroyed. Cellular and organismal homeostasis relies on a balanced activity of the ER folding, quality control, and degradation machineries as shown by the dozens of human…

• NS
  National Science Foundation
• IF
  Institute for Research in Biomedicine
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
• NC
  National Center of Competence in Research Chemical Biology
• UP
  U.S. Public Health Service