Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
Consejo Nacional de Investigaciones Científicas y Técnicas · Universidad de Buenos Aires · +1 more institution
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Abstract
UNLABELLED: Our objective was to estimate the strength of the effect of the I148M (rs738409 C/G) patatin-like phospholipase domain containing 3 (PNPLA3) variant on nonalcoholic fatty liver (NAFLD) and disease severity across different populations. We performed a systematic review by a meta-analysis; literature searches identified 16 studies. Our results showed that rs738409 exerted a strong influence not only on liver fat accumulation (GG homozygous showed 73% higher lipid fat content when compared with CC ones, data from 2,937 subjects; P
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2Topics & keywords
Topics
Keywords
- Nonalcoholic fatty liver disease
- Internal medicine
- Gene
- Gastroenterology
- Disease
- Medicine
- Fatty liver
- Pathology
UN Sustainable Development Goals
- Good health and well-being
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