Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device
University of Duisburg-Essen · Stanford University · +1 more institution
Abstract
Most low-molecular-weight platinum anticancer drugs have short blood circulation times that are reflected in their reduced tumor uptake and intracellular DNA binding. A platinum(IV) complex of the formula c, c, t-[Pt(NH 3) 2Cl 2(O 2CCH 2CH 2CO 2H)(O 2CCH 2CH 2CONH-PEG-FA)] ( 1), containing a folate derivative (FA) at an axial position, was prepared and characterized. Folic acid offers a means of targeting human cells that highly overexpress the folate receptor (FR). Compound 1 was attached to the surface of an amine-functionalized single-walled carbon nanotube (SWNT-PL-PEG-NH 2) through multiple amide linkages to use the SWNTs as a "longboat delivery system" for the platinum warhead, carrying it to the tumor…
Citation impact
- FWCI
- 20.22
- Percentile
- 100%
- References
- 61
Authors
5- SDShanta DharCorresponding
University of Duisburg-Essen, Stanford University, Massachusetts Institute of Technology
- ZLZhuang Liu
Massachusetts Institute of Technology, University of Duisburg-Essen, Stanford University
- JTJürgen Thomale
University of Duisburg-Essen, Massachusetts Institute of Technology, Stanford University
- HDHongjie Dai
University of Duisburg-Essen, Massachusetts Institute of Technology, Stanford University
- SJStephen J. Lippard
University of Duisburg-Essen, Stanford University, Massachusetts Institute of Technology
Topics & keywords
- Chemistry
- Folate receptor
- Biophysics
- Platinum
- Prodrug
- Cisplatin
- Intracellular
- Cancer cell