Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes
Centre National de la Recherche Scientifique · Immunologie, Immunopathologie et Chimie Thérapeutique · +2 more institutions
Abstract
Tasty tubes: Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by mammalian cells (see picture) without the toxic effects typically displayed upon treatment with AmB. Furthermore, the modified drug exhibits a higher antifungal activity than native AmB.
Citation impact
- FWCI
- 18.06
- Percentile
- 100%
- References
- 31
Authors
9- WWWei Wu
Centre National de la Recherche Scientifique, Immunologie, Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moléculaire et Cellulaire
- SWSébastien Wieckowski
Centre National de la Recherche Scientifique, Immunologie, Immunopathologie et Chimie Thérapeutique
- GPGiorgia Pastorin
Centre National de la Recherche Scientifique, Immunologie, Immunopathologie et Chimie Thérapeutique
- MBMonica Benincasa
University of Trieste
- CKCédric Klumpp
Centre National de la Recherche Scientifique, University of Trieste, Immunologie, Immunopathologie et Chimie Thérapeutique
Topics & keywords
- Amphotericin B
- Fluorescein isothiocyanate
- Antifungal
- Carbon nanotube
- Isothiocyanate
- Drug delivery
- Nanotechnology
- Antifungal drug