Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin

Abstract Background Membrane proteins form key nodes in mediating the cell's interaction with the surroundings, which is one of the main reasons why the majority of drug targets are membrane proteins. Results Here we mined the human proteome and identified the membrane proteome subset using three prediction tools for alpha-helices: Phobius, TMHMM, and SOSUI. This dataset was reduced to a non-redundant set by aligning it to the human genome and then clustered with our own interactive implementation of the ISODATA algorithm. The genes were classified and each protein group was manually curated, virtually evaluating each sequence of the clusters, applying systematic comparisons with a range of databases and other…

• MI
  Massachusetts Institute of Technology
• BI
  Broad Institute
• GG
  Göran Gustafssons Stiftelser
• NN
  Novo Nordisk
• V
  Vetenskapsrådet
• MB
  Magnus Bergvalls Stiftelse
• SU
  Stockholms Universitet
• NN
  Novo Nordisk Fonden