Broad targeting of resistance to apoptosis in cancer
The Barbara Ann Karmanos Cancer Institute · Hamad Medical Corporation · +33 more institutions
Abstract
Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminate malignant cells. However, in cancer, de-regulated apoptotic signaling, particularly the activation of an anti-apoptotic systems, allows cancer cells to escape this program leading to uncontrolled proliferation resulting in tumor survival, therapeutic resistance and recurrence of cancer. This resistance is a complicated phenomenon that emanates from the interactions of various molecules and signaling pathways. In this comprehensive review we discuss the various factors contributing to apoptosis resistance in cancers.…
Citation impact
- FWCI
- 20.48
- Percentile
- 100%
- References
- 539
Authors
39Topics & keywords
- Necroptosis
- Apoptosis
- Cancer
- Cancer research
- Cancer cell
- Programmed cell death
- Signal transduction
- Autophagy
- Good health and well-being
Funding
- JSJackson State University
- BABarbara Ann Karmanos Cancer Institute
- NSNational Science Council
- MOMinistry of Science and Technology, TaiwanAwards: NSC93-2314-B-320-006, NSC94-2314-B-320-002
- TMTaipei Medical UniversityAward: TMU101-AE3-Y19
- NINational Institutes of HealthAwards: R21 1R21CA16984801, R21CA184788, R01 CA12060-01A1, 5G12RR013459-13, 1R21CA17597401, 1R01CA20009, 5R01CA127258-05, P30 CA22453
- NCNational Cancer InstituteAwards: P30 CA22453, CA22453, 5R01CA127258-05, 1R01CA20009, R21CA184788