Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends
University of Pavia · NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry · +1 more institution
Abstract
Telomeres, the DNA-protein complexes located at the end of linear eukaryotic chromosomes, are essential for chromosome stability. Until now, telomeres have been considered to be transcriptionally silent. We demonstrate that mammalian telomeres are transcribed into telomeric repeat-containing RNA (TERRA). TERRA molecules are heterogeneous in length, are transcribed from several subtelomeric loci toward chromosome ends, and localize to telomeres. We also show that suppressors with morphogenetic defects in genitalia (SMG) proteins, which are effectors of nonsense-mediated messenger RNA decay, are enriched at telomeres in vivo, negatively regulate TERRA association with chromatin, and protect chromosome ends from…
Citation impact
- FWCI
- 31.34
- Percentile
- 100%
- References
- 27
Authors
5- CMClaus M. Azzalin
University of Pavia, NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry, École Polytechnique Fédérale de Lausanne
- PRPatrick Reichenbach
University of Pavia, NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry, École Polytechnique Fédérale de Lausanne
- LKLela Khoriauli
University of Pavia, NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry, École Polytechnique Fédérale de Lausanne
- EGElena Giulotto
University of Pavia, NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry, École Polytechnique Fédérale de Lausanne
- JLJoachim LingnerCorresponding
University of Pavia, NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry, École Polytechnique Fédérale de Lausanne
Topics & keywords
- Telomere
- Biology
- Subtelomere
- Genetics
- Chromosome
- RNA
- Chromatin
- Telomere-binding protein