Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
University of Washington · Institute of Molecular Biology and Biophysics
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Abstract
The KiSS-1 gene codes for a family of neuropeptides called kisspeptins which bind to the G-protein-coupled receptor GPR54. To assess the possible effects of kisspeptins on gonadotropin secretion, we injected kisspeptin-52 into the lateral cerebral ventricles of adult male rats and found that kisspeptin-52 increased the serum levels of luteinizing hormone (p
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9Topics & keywords
Topics
Keywords
- Kisspeptin
- Endocrinology
- Internal medicine
- Gonadotropin-releasing hormone
- Luteinizing hormone
- Biology
- Hypothalamus
- Neuropeptide
UN Sustainable Development Goals
- Good health and well-being
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