Structure and function of WD40 domain proteins

The WD40 domain exhibits a β-propeller architecture, often comprising seven blades. The WD40 domain is one of the most abundant domains and also among the top interacting domains in eukaryotic genomes. In this review, we will discuss the identification, definition and architecture of the WD40 domains. WD40 domain proteins are involved in a large variety of cellular processes, in which WD40 domains function as a protein-protein or protein-DNA interaction platform. WD40 domain mediates molecular recognition events mainly through the smaller top surface, but also through the bottom surface and sides. So far, no WD40 domain has been found to display enzymatic activity. We will also discuss the different binding…

• G
  GlaxoSmithKline
• OI
  Ontario Innovation Trust
• GC
  Genome Canada
• WT
  Wellcome Trust

  Award: 1097737
• OG
  Ontario Genomics
• OG
  Ontario Genomics Institute
• SF
  Stiftelsen för Strategisk Forskning
• UO
  University of Toronto
• KI
  Karolinska Institutet
• KO
  Knut och Alice Wallenbergs Stiftelse