Ink4a/Arf expression is a biomarker of aging
University of North Carolina at Chapel Hill · Bipar · +2 more institutions
Abstract
The Ink4a/Arf locus encodes 2 tumor suppressor molecules, p16INK4a and Arf, which are principal mediators of cellular senescence. To study the links between senescence and aging in vivo, we examined Ink4a/Arf expression in rodent models of aging. We show that expression of p16INK4a and Arf markedly increases in almost all rodent tissues with advancing age, while there is little or no change in the expression of other related cell cycle inhibitors. The increase in expression is restricted to well-defined compartments within each organ studied and occurs in both epithelial and stromal cells of diverse lineages. The age-associated increase in expression of p16INK4a and Arf is attenuated in the kidney, ovary, and…
Citation impact
- FWCI
- 15.89
- Percentile
- 100%
- References
- 65
Authors
7Topics & keywords
- Senescence
- Biology
- Effector
- Biomarker
- Gene expression
- Suppressor
- Gene expression profiling
- Cancer research
- Good health and well-being