articleJournal of Neurology Neurosurgery & PsychiatryMar 14, 2011GREEN OA

Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study

Neuroscience Institute · Azienda Ospedaliero Universitaria San Giovanni Battista · +2 more institutions

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Abstract

Background

Different amyotrophic lateral sclerosis (ALS) phenotypes have been recognised, marked by a varying involvement of spinal and bulbar upper and lower motor neurons. However, the differential characteristics of these phenotypes are still largely unknown.

Objective

To define the epidemiology and outcome of ALS phenotypes in a population based setting.

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