Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status and AD neuropathologic changes. Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. Worldwide research efforts have evaluated thousands of human subjects to assess the causes of cognitive impairment in the elderly, and these studies have been interpreted in different…

• AA
  Alzheimer's Association
• AF
  Alzheimer Forschung Initiative
• AS
  Alzheimer's Society
• DF
  Deutsche Forschungsgemeinschaft
• MR
  Medical Research Council