Selenium in Human Health and Disease
University of East Anglia · University of Nottingham · +1 more institution
Abstract
This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. Selenium toxicity and links between deficiency and Keshan disease and Kashin-Beck disease are described. The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility, are reviewed, and recent developments in genetics of selenoproteins are outlined. The rationale behind current dietary reference intakes of selenium is explained, and examples of differences…
Citation impact
- FWCI
- 31.27
- Percentile
- 100%
- References
- 427
Authors
7Topics & keywords
- Selenium
- Selenoprotein
- Selenium deficiency
- Disease
- Environmental health
- Antioxidant
- Biology
- Biotechnology