Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer
University of Alberta · University of Alberta Hospital · +3 more institutions
Abstract
The role of platelets in tumor progression and metastasis has been recognized but the mechanism of their action remains unclear. Five human lung cancer cell lines (A549, CRL 2066, CRL 2062, HTB 183, HTB 177) and a murine Lewis lung carcinoma (LCC) cell line (for an in vivo model of metastasis) were used to investigate how platelet-derived microvesicles (PMV), which are circular fragments shed from the surface membranes of activated platelets, and exosomes released from platelet alpha-granules, could contribute to metastatic spread. We found that PMV transferred the platelet-derived integrin CD41 to most of the lung cancer cell lines tested and stimulated the phosphorylation of mitogen-activated protein kinase…
Citation impact
- FWCI
- 4.22
- Percentile
- 100%
- References
- 54
Authors
7- AJAnna Janowska‐Wieczorek
University of Alberta, University of Alberta Hospital, Pomeranian Medical University, Canadian Blood Services
- MWMarcin Wysoczynski
University of Louisville, Pomeranian Medical University
- JKJacek Kijowski
University of Louisville, Pomeranian Medical University
- LALeah A. Marquez‐Curtis
Pomeranian Medical University, Canadian Blood Services
- BMBogdan Machalinski
University of Louisville, Pomeranian Medical University
Topics & keywords
- Cancer research
- Microvesicles
- Angiogenesis
- Metastasis
- Biology
- Matrigel
- Lewis lung carcinoma
- Vascular endothelial growth factor
- Good health and well-being