Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study
Johns Hopkins University · University of Florida · +14 more institutions
Abstract
Minimal residual disease (MRD) is an important predictor of relapse in acute lymphoblastic leukemia (ALL), but its relationship to other prognostic variables has not been fully assessed. The Children's Oncology Group studied the prognostic impact of MRD measured by flow cytometry in the peripheral blood at day 8, and in end-induction (day 29) and end-consolidation marrows in 2143 children with precursor B-cell ALL (B-ALL). The presence of MRD in day-8 blood and day-29 marrow MRD was associated with shorter event-free survival (EFS) in all risk groups; even patients with 0.01% to 0.1% day-29 MRD had poor outcome compared with patients negative for MRD patients (59% +/- 5% vs 88% +/- 1% 5-year EFS). Presence of…
Citation impact
- FWCI
- 43.93
- Percentile
- 100%
- References
- 84
Authors
13- MJMichael J. BorowitzCorresponding
Johns Hopkins University
- MDMeenakshi Devidas
University of Florida, Children's Oncology Group
- SPStephen P. Hunger
Children's Hospital Colorado, University of Colorado Denver
- WPW. Paul Bowman
Johns Hopkins University, Cook Children's Medical Center
- AJAndrew J. Carroll
University of Alabama at Birmingham
Topics & keywords
- Minimal residual disease
- Medicine
- Internal medicine
- Oncology
- Leukemia