A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
The Ohio State University · University of Ferrara · +3 more institutions
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Abstract
Background
MicroRNA expression profiles can be used to distinguish normal B cells from malignant B cells in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL.
Methods
We evaluated the microRNA expression profiles of 94 samples of CLL cells for which the level of expression of 70-kD zeta-associated protein (ZAP-70), the mutational status of the rearranged immunoglobulin heavy-chain variable-region (IgV(H) ) gene, and the time from diagnosis to initial treatment were known. We also investigated the genomic sequence of 42 microRNA genes to identify abnormalities.
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2,412
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Authors
23Topics & keywords
Topics
Keywords
- Chronic lymphocytic leukemia
- microRNA
- Medicine
- Leukemia
- Oncology
- Immunology
- Cancer research
- Gene
UN Sustainable Development Goals
- Good health and well-being
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