Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism
Johns Hopkins University · Johns Hopkins Medicine · +1 more institution
Abstract
Recent studies of genomic variation associated with autism have suggested the existence of extreme heterogeneity. Large-scale transcriptomics should complement these results to identify core molecular pathways underlying autism. Here we report results from a large-scale RNA sequencing effort, utilizing region-matched autism and control brains to identify neuronal and microglial genes robustly dysregulated in autism cortical brain. Remarkably, we note that a gene expression module corresponding to M2-activation states in microglia is negatively correlated with a differentially expressed neuronal module, implicating dysregulated microglial responses in concert with altered neuronal activity-dependent genes in…
Citation impact
- FWCI
- 21.34
- Percentile
- 100%
- References
- 58
Authors
8- SGSimone Gupta
Johns Hopkins University, Johns Hopkins Medicine
- SEShannon Ellis
Johns Hopkins University, Johns Hopkins Medicine
- FNForam N. Ashar
Johns Hopkins University, Johns Hopkins Medicine
- AMAnna Moes
Johns Hopkins University, Johns Hopkins Medicine
- JSJoel S. Bader
Johns Hopkins University, Johns Hopkins Medicine
Topics & keywords
- Transcriptome
- Autism
- Innate immune system
- Biology
- Gene
- Neuroscience
- Microglia
- Gene expression
- Good health and well-being