Electronic dura mater for long-term multimodal neural interfaces

Minev, Ivan R.; Musienko, Pavel; Hirsch, Arthur; Barraud, Quentin; Wenger, Nikolaus; Moraud, Eduardo Martin; Gandar, Jérôme; Capogrosso, Marco; Milekovic, Tomislav; Asboth, Léonie; Torres, Rafael Fajardo; Vachicouras, Nicolas; Liu, Qihan; Pavlova, Natalia; Duis, Simone; Larmagnac, Alexandre; Vörös, János; Micera, Silvestro; Suo, Zhigang; Courtine, Grégoire; Lacour, Stéphanie P.

doi:10.1126/science.1260318

articleScienceJan 9, 2015GREEN OA

Electronic dura mater for long-term multimodal neural interfaces

IRIvan R. Minev PMPavel Musienko AHArthur Hirsch QBQuentin Barraud NWNikolaus Wenger

École Polytechnique Fédérale de Lausanne · Pavlov Institute of Physiology of the Russian Academy of Sciences · +6 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal…

Citation impact

1,061

total citations

FWCI: 39.70
Percentile: 100%
References: 33

Citations per year

Authors

21

Topics & keywords

Topics

Keywords

Dura mater
Brain–computer interface
Biomedical engineering
Neuroprosthetics
Spinal cord
Neuromodulation
Brain implant
Materials science

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.