Predominant Autoantibody Production by Early Human B Cell Precursors
Hospital for Special Surgery · Memorial Sloan Kettering Cancer Center · +3 more institutions
Abstract
During B lymphocyte development, antibodies are assembled by random gene segment reassortment to produce a vast number of specificities. A potential disadvantage of this process is that some of the antibodies produced are self-reactive. We determined the prevalence of self-reactive antibody formation and its regulation in human B cells. A majority (55 to 75%) of all antibodies expressed by early immature B cells displayed self-reactivity, including polyreactive and anti-nuclear specificities. Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development. Inefficient checkpoint regulation would lead to substantial increases in circulating autoantibodies.
Citation impact
- FWCI
- 43.79
- Percentile
- 100%
- References
- 33
Authors
6- HWHedda Wardemann
Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute, Cornell University, Rockefeller University
- SYSergey Yurasov
Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute, Cornell University, Rockefeller University
- ASAnne Schaefer
Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute, Cornell University, Rockefeller University
- JWJames W. Young
Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute, Cornell University, Rockefeller University
- EMEric MeffreCorresponding
Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute, Cornell University, Rockefeller University
Topics & keywords
- Autoantibody
- Antibody
- Immunology
- Biology
- Population
- B cell
- Medicine