Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
Brigham and Women's Hospital · Harvard University · +2 more institutions
Abstract
Two substrates of insulin-degrading enzyme (IDE), amyloid beta-protein (Abeta) and insulin, are critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2), respectively. We previously identified IDE as a principal regulator of Abeta levels in neuronal and microglial cells. A small chromosomal region containing a mutant IDE allele has been associated with hyperinsulinemia and glucose intolerance in a rat model of DM2. Human genetic studies have implicated the IDE region of chromosome 10 in both AD and DM2. To establish whether IDE hypofunction decreases Abeta and insulin degradation in vivo and chronically increases their levels, we characterized mice with homozygous…
Citation impact
- FWCI
- 31.95
- Percentile
- 100%
- References
- 61
Authors
10- WFWesley FarrisCorresponding
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Mayo Clinic in Florida
- SMStefan Mansourian
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Mayo Clinic in Florida
- YCYang Chang
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Mayo Clinic in Florida
- LLLoren Lindsley
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Mayo Clinic in Florida
- EAElizabeth A. Eckman
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Mayo Clinic in Florida
Topics & keywords
- Insulin-degrading enzyme
- Hyperinsulinemia
- Biology
- Endocrinology
- Insulin
- Internal medicine
- Amyloid precursor protein
- Amyloid (mycology)
- Good health and well-being