Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
Howard Hughes Medical Institute · University of Wisconsin–Madison · +2 more institutions
Abstract
Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of human germ cell tumors, we compared the expression profiles of human ES cell lines, human germ cell tumor cell lines and tumor samples, somatic cell lines, and testicular tissue samples by using cDNA microarray analysis. Hierarchical cluster analysis of gene expression profiles showed that the five independent human ES cell lines clustered tightly together, reflecting highly similar expression profiles. The gene…
Citation impact
- FWCI
- 17.41
- Percentile
- 100%
- References
- 60
Authors
10- JMJamie M. SpergerCorresponding
Howard Hughes Medical Institute, University of Wisconsin–Madison, University of Sheffield, Stanford University
- XCXin Chen
Howard Hughes Medical Institute, University of Wisconsin–Madison, University of Sheffield, Stanford University
- JSJonathan S. Draper
Howard Hughes Medical Institute, University of Wisconsin–Madison, University of Sheffield, Stanford University
- JEJessica E. Antosiewicz
Howard Hughes Medical Institute, University of Wisconsin–Madison, University of Sheffield, Stanford University
- CHChris H. Chon
Howard Hughes Medical Institute, University of Wisconsin–Madison, University of Sheffield, Stanford University
Topics & keywords
- Biology
- Induced pluripotent stem cell
- Embryonic stem cell
- Embryonal carcinoma
- Somatic cell
- Germ cell
- Gene expression
- Seminoma
- Good health and well-being