Aberrant repair and fibrosis development in skeletal muscle
Universitat Pompeu Fabra · Biomedical Research Networking Center on Neurodegenerative Diseases · +1 more institution
Abstract
The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem cells orchestrate their activities to restore tissue homeostasis. However, during chronic tissue damage, such as in muscular dystrophies, the inflammatory-cell infiltration and fibroblast activation persists, while the reparative capacity of stem cells (satellite cells) is attenuated. Abnormal dystrophic muscle repair and its end stage, fibrosis, represent the final common pathway of virtually all chronic neurodegenerative muscular diseases. As our understanding of the pathogenesis of muscle…
Citation impact
- FWCI
- 14.90
- Percentile
- 100%
- References
- 129
Authors
7- CJChristopher J. MannCorresponding
Universitat Pompeu Fabra, Biomedical Research Networking Center on Neurodegenerative Diseases
- EPEusebio Perdiguero
Universitat Pompeu Fabra, Biomedical Research Networking Center on Neurodegenerative Diseases
- YKYacine Kharraz
Universitat Pompeu Fabra, Biomedical Research Networking Center on Neurodegenerative Diseases
- SASusana Aguilar
Universitat Pompeu Fabra, Biomedical Research Networking Center on Neurodegenerative Diseases
- PPPatrizia Pessina
Universitat Pompeu Fabra, Biomedical Research Networking Center on Neurodegenerative Diseases
Topics & keywords
- Fibrosis
- Extracellular matrix
- Stem cell
- Wound healing
- Skeletal muscle
- Regeneration (biology)
- Pathology
- Cell biology
- Good health and well-being