Point of Care Diagnostics: Status and Future

The most commonly used test for monitoring heparin therapy is the activated partial thromboplastin time (aPTT). The response of available aPTT reagents to heparin varies significantly. The aim of this study was to highlight the differences between aPTT reagents stored in a dried format to select the most suitable formulations to be used for the development of point-of-care diagnostic devices used for monitoring of unfractionated heparin dose response. METHODS:\nTen reagents were analysed in terms of their performance in liquid and in dried form after storage for 24 h and 14 days. Performance was assessed by measurement of the clotting time (CT) as evidenced by the onset of thrombin formation using a…

• NA
  National Aeronautics and Space Administration
• MI
  Massachusetts Institute of Technology
• CI
  California Institute of Technology
• UC
  University College London
• UO
  University of Auckland
• SF
  Science Foundation Ireland
• UC
  University College Dublin
• DC
  Dublin City University
• UH
  Universität Heidelberg
• TU
  Technological University Dublin
• DF
  Directorate for Biological Sciences
• AR
  Ames Research Center
• UO
  University of California, Irvine
• LL
  Lawrence Livermore National Laboratory
• SN
  Sandia National Laboratories