TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy
Massachusetts General Hospital · United States Department of Veterans Affairs · +5 more institutions
Abstract
Epidemiological evidence suggests that the incidence of amyotrophic lateral sclerosis is increased in association with head injury. Repetitive head injury is also associated with the development of chronic traumatic encephalopathy (CTE), a tauopathy characterized by neurofibrillary tangles throughout the brain in the relative absence of β-amyloid deposits. We examined 12 cases of CTE and, in 10, found a widespread TAR DNA-binding protein of approximately 43kd (TDP-43) proteinopathy affecting the frontal and temporal cortices, medial temporal lobe, basal ganglia, diencephalon, and brainstem. Three athletes with CTE also developed a progressive motor neuron disease with profound weakness, atrophy, spasticity,…
Citation impact
- FWCI
- 31.02
- Percentile
- 100%
- References
- 77
Authors
16- ACAnn C. McKeeCorresponding
Massachusetts General Hospital, United States Department of Veterans Affairs, Emerson Hospital, Harvard University, Geriatric Research Education and Clinical Center, Icahn School of Medicine at Mount Sinai, Boston University
- BEBrandon E. Gavett
Harvard University, Emerson Hospital, Icahn School of Medicine at Mount Sinai, Geriatric Research Education and Clinical Center, Boston University, Massachusetts General Hospital
- RARobert A. Stern
Harvard University, Icahn School of Medicine at Mount Sinai, Geriatric Research Education and Clinical Center, Massachusetts General Hospital, Emerson Hospital, Boston University
- CJChristopher J. Nowinski
Harvard University, Massachusetts General Hospital, Icahn School of Medicine at Mount Sinai, Emerson Hospital, Boston University, Geriatric Research Education and Clinical Center
- RCRobert C. Cantu
Icahn School of Medicine at Mount Sinai, Boston University, Emerson Hospital, Massachusetts General Hospital, Harvard University, Geriatric Research Education and Clinical Center
Topics & keywords
- Chronic traumatic encephalopathy
- Amyotrophic lateral sclerosis
- Frontotemporal lobar degeneration
- Motor neuron
- Fasciculation
- Neuroscience
- Tauopathy
- Spinal cord
- Good health and well-being