Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context
Brown University · Center for Environmental Health · +7 more institutions
Abstract
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividual epigenetic variations in normal tissues due to aging, environmental factors, or innate susceptibility are poorly characterized. The plasticity, tissue-specific nature, and variability of gene expression are related to epigenomic states that vary across individuals. Thus, population-based investigations are needed to further our understanding of the fundamental dynamics of normal individual epigenomes. We analyzed 217 non-pathologic human tissues from 10 anatomic…
Citation impact
- FWCI
- 29.82
- Percentile
- 100%
- References
- 56
Authors
14- BCBrock C. Christensen
Brown University, Center for Environmental Health
- EAE. Andrés Houseman
Center for Environmental Health, Brown University, Harvard University
- CJCarmen J. Marsit
Brown University
- SZShichun Zheng
Neurological Surgery, University of California, San Francisco
- MWMargaret Wrensch
Neurological Surgery, University of California, San Francisco
Topics & keywords
- DNA methylation
- Biology
- CpG site
- Epigenetics
- Epigenomics
- Methylation
- Genetics
- Context (archaeology)
- Life below water