Genomic analysis of the host response to hepatitis C virus infection

Su, Andrew I.; Pezacki, John Paul; Wodicka, Lisa; Brideau, Amy D.; Supeková, Ľubica; Thimme, Robert; Wieland, Stefan; Bukh, Jens; Purcell, Robert H.; Schultz, Peter G.; Chisari, Francis V.

doi:10.1073/pnas.202608199

articleProceedings of the National Academy of SciencesNov 19, 2002GREEN OA

Genomic analysis of the host response to hepatitis C virus infection

AIAndrew I. Su JPJohn Paul Pezacki LWLisa Wodicka ADAmy D. Brideau ĽSĽubica Supeková

Scripps Research Institute · Genomics Institute of the Novartis Research Foundation · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

We have examined the progression of hepatitis C virus (HCV) infections by gene expression analysis of liver biopsies in acutely infected chimpanzees that developed persistent infection, transient viral clearance, or sustained clearance. Both common responses and outcome-specific changes in expression were observed. All chimpanzees showed gene expression patterns consistent with an IFN-alpha response that correlated with the magnitude and duration of infection. Transient and sustained viral clearance were uniquely associated with induction of IFN-gamma-induced genes and other genes involved in antigen processing and presentation and the adaptive immune response. During the early stages of infection, host genes…

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1,163

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Topics & keywords

Topics

Keywords

Biology
Gene
Immune system
Virus
Hepatitis C virus
Virology
Viral replication
Gene expression

UN Sustainable Development Goals

Good health and well-being

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