A2A adenosine receptor protects tumors from antitumor T cells
Northeastern University · National Institutes of Health · +8 more institutions
Abstract
The A2A adenosine receptor (A2AR) has been shown to be a critical and nonredundant negative regulator of immune cells in protecting normal tissues from inflammatory damage. We hypothesized that A2AR also protects cancerous tissues by inhibiting incoming antitumor T lymphocytes. Here we confirm this hypothesis by showing that genetic deletion of A2AR in the host resulted in rejection of established immunogenic tumors in approximately 60% of A2AR-deficient mice with no rejection observed in control WT mice. The use of antagonists, including caffeine, or targeting the A2 receptors by siRNA pretreatment of T cells improved the inhibition of tumor growth, destruction of metastases, and prevention of…
Citation impact
- FWCI
- 13.41
- Percentile
- 100%
- References
- 50
Authors
15- AOAkio OhtaCorresponding
Northeastern University, National Institutes of Health, National Institute of Allergy and Infectious Diseases
- EGElieser Gorelik
UPMC Hillman Cancer Center
- SJSimon J. Prasad
Malaghan Institute of Medical Research
- FRFranca Ronchese
Malaghan Institute of Medical Research
- DLDmitriy Lukashev
Northeastern University, National Institutes of Health, National Institute of Allergy and Infectious Diseases
Topics & keywords
- Immune system
- Cancer research
- Tumor microenvironment
- Adenosine
- Adenosine receptor
- Autoimmunity
- Cancer immunotherapy
- Immunology
- Good health and well-being