Molecular Testing for Mutations in Improving the Fine-Needle Aspiration Diagnosis of Thyroid Nodules
University of Pittsburgh · University of Cincinnati Medical Center · +2 more institutions
Abstract
The aim of this study was to establish the feasibility and role of testing for tumor-specific mutations in improving the FNA diagnosis of thyroid nodules.
The prospective study included 470 FNA samples of thyroid nodules from 328 patients. At the time of aspiration, a small portion of the material was collected and tested for BRAF, RAS, RET/PTC, and PAX8/PPARgamma mutations. The mutational status was correlated with cytology and either surgical pathology diagnosis or follow-up (mean, 34 months).
Citation impact
- FWCI
- 36.62
- Percentile
- 100%
- References
- 46
Authors
10- YEYuri E. NikiforovCorresponding
University of Pittsburgh, University of Cincinnati Medical Center
- DLDavid L. Steward
University of Cincinnati Medical Center
- TMToni M. Robinson-Smith
University of Cincinnati Medical Center
- BRBryan R. Haugen
University of Colorado Denver, University of Colorado Cancer Center
- JKJoshua Klopper
University of Colorado Denver, University of Colorado Cancer Center
Topics & keywords
- Thyroid nodules
- Fine-needle aspiration
- Thyroid
- Medicine
- Pathology
- Radiology
- Internal medicine
- Biopsy
- Good health and well-being